生物活性：Vinpocetine-d5 is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders[1][2][3].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Vinpocetine-d5 相关抗体:
Phospho-IKB alpha (Ser32) Antibody (YA183)
TBK1 Antibody (YA662)
IKK beta Antibody
TBK1 Antibody (YA040)
xCT Antibody (YA006)
IKK alpha Antibody
IKK alpha + IKK beta Antibody
IKK gamma Antibody
xCT Antibody (YA652)
IKB alpha Antibody
Phospho-IKB alpha (Ser32) Antibody (YA185)
Phospho-IKB alpha (Ser36) Antibody
Alpha-ENaC Antibody
PDE1B Antibody (YA1553)
IKK alpha/beta Antibody (YA1871)
PDE4B Antibody (YA2932)
PDE2A Antibody (YA2989)
CRMP2 Antibody (YA3370)
SLC12A1 Antibody (YA1403)
IKK epsilon Antibody (YA1611)
PDE4D Antibody (YA1714)
CRMP1 Antibody (YA1941)
TAB1 Antibody (YA1951)
CRMP5 Antibody (YA2497)
CRMP3 Antibody (YA2563)
CRMP4 Antibody (YA2777)
IKB epsilon Antibody (YA3012)
IKB beta Antibody (YA3088)
分子量：355.48
Formula：C22H21D5N2O2
CAS 号：2734920-39-7
非标记 CAS：42971-09-5
中文名称：长春西汀 d5
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (542 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Kye-Im Jeon et al. Vinpocetine inhibits NF-κB-dependent inflammation via an IKK-dependent but PDE-independent mechanism PNAS May 25, 2010 vol. 107 no. 21 9795-9800
[3]. Patyar S, et al. Role of vinpocetine in cerebrovascular diseases. Pharmacol Rep. 2011;63(3):618-28.
 [Content Brief]
[4]. Alexandre E. Medina Vinpocetine as a potent antiinflammatory agent PNAS June 1, 2010, Vol. 107, No. 22 9921-9922.